Monday, November 16, 2009

Stroke survivor support brings recognition for Central Coast women - Express Advocate Wyong

US Army's new weapon is thinking positively

http://www.smh.com.au/world/us-armys-new-weapon-is-thinking-positively-20091116-iicg.html

FACED with rising rates of depression, post traumatic stress disorder, drug abuse and suicide among its war-weary soldiers, the Pentagon has turned to the founder of positive psychology, Martin Seligman, to train its troops in how to lead happier lives.

The aim of the four-year program is to make the US Army ''just as psychologically fit as physically fit'', Professor Seligman told the Herald, as a vanguard of more than 150 sergeants learnt about emotional resilience at his University of Pennsylvania research centre.

Despite their ''grizzled'' tough guy images, sergeants are in the best position to pass on psychological coping skills to soldiers in their command in a bid to prevent mental problems developing.

''They are the teachers in the army,'' said Professor Seligman, who will visit Sydney next month to address a scientific forum with the Dalai Lama at the Mind and Its Potential conference in Darling Harbour.

At the forum he will present results of 17 controlled studies of his team's resilience training in schools, published recently in theOxford Review of Education, which show it can reduce hopelessness and prevent depression, in some cases halving the rate of moderate to severe depressive symptoms in young people.

Two years ago, Geelong Grammar School in Victoria was the first to introduce this positive psychology approach across a whole institution, and the program only needed to be slightly modified to suit the million-strong army, Professor Seligman said.

''The sergeants will receive basically the same kind of training Geelong Grammar teachers had.''

New technology has dramatically changed overseas service for US troops, who face repeated deployments to Afghanistan and Iraq. ''This is the first war in which soldiers have cell phones to call home and get into a fight with their spouses about the kids,'' he said.

It meant soldiers could benefit from learning psychological skills to cope with everyday issues, such as how to get along better with partners and co-workers and handle personal rejection. ''A lot of the depression and anxiety and post-traumatic stress disorder [for soldiers] is built up, not only out of combat, but out of the usual losses and stresses of civilian life.''

Positive psychology was not just ''grandmotherly common sense'', he said, but was based on three areas of skills that can be taught and measured, including how to develop positive emotions and engage more in life with activities that make time seem to stop - a so-called state of flow. ''While there are shortcuts to positive emotion - you can take drugs, masturbate, watch television or go shopping - there are no shortcuts to flow,'' said Professor Seligman, who goes into flow playing bridge or tending his roses.

The third key to happiness was to lead a meaningful life, ''knowing what your highest strengths are and then using them to belong to and serve something you believe is larger than the self''.

Like Australian school students, the soldiers will also be taught to avoid catastrophising events, and jumping to the worst-case scenario if, for example, a comrade goes missing.

Worrying about developing post-traumatic stress disorder can lead to a self-fulfilling, downward spiral. Soldiers need to know that post-traumatic growth, in which horrific experiences can make people emotionally stronger, is also common, he said.

More than 40 scientists, psychologists and philosophers will speak at the conference on the capacity of the brain to change and develop.

Really?: The Claim: Magnetic Therapy Can Ease Arthritis Pain

Really?: The Claim: Magnetic Therapy Can Ease Arthritis Pain: "Do magnetic straps and bracelets do anything to relieve joint pain?


THE FACTS For people with arthritis who seek an alternative to painkillers, magnetic straps and bracelets have become a popular option.

The devices are said to work by stimulating the release of the body’s natural painkillers or by increasing blood flow to tissue. They are generally considered safe (if expensive), but in recent years a number of studies have found little evidence that they provide any real benefit.

One that did find some benefit was published in 2004 in BMJ and involved 194 people with osteoarthritis of the hip and knee. The scientists found that subjects randomly assigned to wear a full-strength magnetic bracelet for 12 weeks had greater improvements than those wearing a dummy bracelet.

But an analysis of several studies, also in 2004, found that the evidence swung against magnetic therapy for pain relief, and added that while it could not exclude “a clinically important benefit” in the treatment of osteoarthritis, more research was needed.

Then, in a well-designed 16-week study published this year, British scientists compared the effects of a popular magnetic device, a weak magnetic wrist strap, a demagnetized device and a copper bracelet in people with osteoarthritis. Their findings were blunt.

“Our results indicate that magnetic and copper bracelets are generally ineffective for managing pain, stiffness and physical function in osteoarthritis,” they concluded.

THE BOTTOM LINE The evidence supporting magnetic therapy for arthritis pain is limited."

Vital Signs: Exercise: Treating Sleep Apnea With a Golf Club

Vital Signs: Exercise: Treating Sleep Apnea With a Golf Club: "Will treatment outcomes for sleep apnea improve if men with the condition thought treatment might improve their golf game?

Many middle-aged men who have sleep apnea either do not seek treatment or are inconsistent about using the airway pressure masks prescribed to them. But what if they thought treatment might improve their golf game?


Dr. Marc L. Benton, a New Jersey pulmonologist who was convinced that patients would improve their golf game if they slept better, tested his hypothesis by recruiting a dozen avid golfers with untreated sleep apnea for a small, preliminary study. Dr. Benton assessed their daytime sleepiness at the beginning of the study and recorded their golf handicap index.

The patients were then fitted with nasal positive airway pressure masks and told to wear them every night.

Three to five months later, after they had completed 20 new rounds of golf, the players reported using the masks up to 95 percent of the time. Compliance was also tracked electronically.

The participants were less sleepy during the daytime, and their handicap index improved to 11 from an average of 12.4 before treatment, said Dr. Benton, who presented his findings last week at an international conference of the American College of Chest Physicians in San Diego.

The study has not been reviewed for publication. It was limited because it was not a randomized controlled trial, and neither the patients nor the researchers were blinded about the treatment and the expected outcomes."

Sunday, November 15, 2009

A Prospective Blinded Evaluation of Urinary Porphyrins Verses the Clinical Severity of Autism Spectrum Disorders

A Prospective Blinded Evaluation of Urinary Porphyrins Verses the Clinical Severity of Autism Spectrum Disorders
A prospective, blinded study evaluated the relationship between autism spectrum disorder (ASD) severity measured by Childhood Autism Rating Scale (CARS) scores and urinary porphyrins among a cohort of participants (n = 26). LabCorp (CLIA-approved) tested for uroporphyrins, heptacarboxylporphyrins, hexacarboxylporphyrins, pentacarboxylporphyrins, coproporphyrin (cP) I, and cP III levels. Participants with severe ASD had significantly increased cP I, cP III, and total cP levels in comparison to participants with mild ASD. A significant correlation was observed between increasing cP levels and CARS scores. Significant correlations were also noted for comparative urinary porphyrin testing between LabCorp and the Laboratoire Philippe Auguste (ISO-approved) for total cP. Finally, total cP measured at LabCorp was found to significantly correlate with precoproporphryin (a specific porphyrin marker for mercury toxicity) measured at the Laboratoire Philippe Auguste. Since urinary porphyrin testing is clinically available, relatively inexpensive, and noninvasive, it may be used to help suggest whether heavy metal toxicity is associated with ASD.

Repeated Measures of Validated and Novel Biomarkers of Exposure to Polycyclic Aromatic Hydrocarbons in Individuals Living Near an Aluminum Plant in Qu

Repeated Measures of Validated and Novel Biomarkers of Exposure to Polycyclic Aromatic Hydrocarbons in Individuals Living Near an Aluminum Plant in Quebec, Canada
A longitudinal biomonitoring study was conducted to assess exposure to polycyclic aromatic hydrocarbons (PAH) in non-occupationally exposed nonsmoking adults living in the vicinity of an aluminum plant. Metabolites of several PAH (pyrene, naphthalene, chrysene, fluoranthene, benz[a]anthracene) were measured in the urine of the participants, including 1-hydroxypyrene (1-OHP) as a validated biomarker and pyrene diones as novel biomarkers. In total, 73 individuals living about 1 km away from the plant (taken as the exposed group) were compared repeatedly with 71 individuals living at least 11 km from the smelter (used as the control group). Complete first morning voids were collected twice, at a 2-wk interval, in the fall of 2005 and twice weekly for 2 consecutive weeks in the spring of 2006. Urinary biomarker concentrations were then measured by an ultra-performance liquid chromatography (UPLC) method with time-of-flight mass spectrometry detection (MS-TOF) (UPLC-MS-TOF). For most sampling days, individuals living near the plant showed significantly higher excretion values of both 1-OHP and pyrene diones (mean ratio up to 2- and 2.4-fold, respectively) than individuals living further from the plant. In the group living near the plant, geometric mean concentrations of 1-OHP varied from 0.047 to 0.058 μmol/mol creatinine, depending on the sampling day, as compared to 0.025 to 0.04 μmol/mol creatinine in the reference group. Corresponding mean values for pyrene diones were 0.017-0.056 μmol/mol creatinine and 0.014-0.039 μmol/mol creatinine, respectively. Urinary 1- and 2-naphthols were also measured as a reference and showed no significant differences between the two groups for most sampling days; metabolite concentrations of the other monitored PAH (chrysene, fluoranthene, benz[a]anthracene) were mostly below the analytical limit of detection of 0.005 to 0.01 μg/L, depending on the metabolite, with a detection rate varying from 0 to at most 21%. Individuals living near the aluminum plant thus appeared to be repeatedly exposed to higher pyrene levels than the control group, on the basis of both 1-OHP and pyrene dione excretions. However, 1-OHP concentrations observed in this first group were similar to those of other reference populations of nonsmokers studied in the past. Uptake of the other PAH associated with plant emissions was too small to significantly increase the excretion of their metabolites.

An Evaluation of Surrogate Chemical Exposure Measures and Autism Prevalence in Texas

An Evaluation of Surrogate Chemical Exposure Measures and Autism Prevalence in Texas
There is currently considerable discussion in the scientific community as well as within the general public concerning the role mercury (Hg) exposures may play in the apparent increased incidence of neurodevelopmental disorders (particularly autism) in children. Although the primary focus of this debate has focused on ethylmercury from vaccinations, linkage to other sources of Hg has been proposed. An ecologic association between 2001 Toxic Release Inventory (TRI; www.epa.gov/tri) data for Hg and 2000-2001 school district autism prevalence was previously reported in Texas. Evaluations using industrial release data as surrogate exposure measures may be problematic, particularly for chemicals like Hg that have complex environmental fates. To explore the robustness of TRI-based analyses of the Hg-autism hypothesis in Texas, a detailed analysis was undertaken examining the extent of the ecological relationship during multiple years and examining whether surrogate exposure measures would yield similar conclusions. Using multilevel Poisson regression analysis and data obtained from a number of publicly available databases, it was found that air Hg release data were significantly associated with autism prevalence in Texas school districts when considering data for 2001 and 2002 (2001: RR = 4.45, 95% CI = 1.60-12.36, 2002: RR = 2.70, 95% CI = 1.17-6.15). Significant associations were not found using data from 2003 to 2005. A significant association was not observed when considering air Hg data for 2000 or 2001 and school district autism prevalence data for 2005-2006 or 2006-2007, an analysis allowing for a 5-yr time period between presumed exposure and entry into the public school system (2000: RR = 1.03, 95% CI = 0.59-1.83, 2001: RR = 0.94, 95% CI = 0.59-1.47). Significant associations were not observed for any year nor for the time lagged analyses when censored autism counts were replaced by threes instead of zeros. An evaluation of TRI air emissions data for several other pollutants did not find significant associations except for nickel (RR = 1.71, 1.12-2.60), which has no history of being associated with neurodevelopmental disorders. An evaluation using downwind location from coal-fired power plants as the exposure surrogate variable also did not yield statistically significant results. The analysis suggests Hg emissions are not consistently associated with autism prevalence in Texas school districts. The lack of consistency across time may be the result of the influence of a more significant factor which remains unidentified. Alternatively, it may be that the significant association observed in 2001 and 2002 does not represent a true causal association.

Urinary Porphyrin Excretion in Children with Mercury Amalgam Treatment: Findings from the Casa Pia Children's Dental Amalgam Trial

Urinary Porphyrin Excretion in Children with Mercury Amalgam Treatment: Findings from the Casa Pia Children's Dental Amalgam Trial

Increases in the urinary concentrations of pentacarboxyl- and coproporphyrins and the appearance of the atypical precoproporphyrin have been defined in relation to mercury (Hg) body burden in animal studies, and this change in the porphyrin excretion pattern has been described as a biomarker of occupational Hg exposure and toxicity in adult human subjects. In the present studies, urinary porphyrins were determined in relation to Hg exposure in children and adolescents, 8-18 yr of age, over the 7-yr course of a clinical trial designed to evaluate the neurobehavioral and renal effects of dental amalgam in children. Subjects were randomized to either dental amalgam or composite resin treatments. Urinary porphyrins and creatinine concentrations were measured at baseline and annually in all subjects. Results were evaluated using linear regression analysis. No significant differences between treatment groups (amalgam versus composite) were found when comparing all subjects for any of the porphyrins of interest. However, incipent amalgam treatment-specific increases were observed in the mean concentrations of penta-, precopro- and coproporphyrins especially when the analyses were restricted to younger subjects (8 to 9 yr old at baseline), and these increases were most apparent during yr 2 through 3 of follow-up, the period of highest mercury exposure from amalgam treatment. Based on the mean number of amalgam fillings received by children in this group (17.8), the renal Hg concentration associated with incipient increases in urinary porphyrins was estimated to be approximately 2.7 μg/g renal cortex. This value corresponds to an observed mean urinary Hg concentration of 3.2 μg/g creatinine, which is approximately fivefold less than that at which renal damage from Hg exposure is estimated to occur in children. These findings are consistent with growing evidence supporting the sensitivity of urinary porphyrins as a biological indicator of subclinical Hg exposure in children.

Neurocognitive Screening of Lead-Exposed Andean Adolescents and Young Adults

Neurocognitive Screening of Lead-Exposed Andean Adolescents and Young Adults
This study was designed to assess the utility of two psychometric tests with putative minimal cultural bias for use in field screening of lead (Pb)-exposed Ecuadorian Andean workers. Specifically, the study evaluated the effectiveness in Pb-exposed adolescents and young adults of a nonverbal reasoning test standardized for younger children, and compared the findings with performance on a test of auditory memory. The Raven Coloured Progressive Matrices (RCPM) was used as a test of nonverbal intelligence, and the Digit Span subtest of the Wechsler IV intelligence scale was used to assess auditory memory/attention. The participants were 35 chronically Pb-exposed Pb-glazing workers, aged 12-21 yr. Blood lead (PbB) levels for the study group ranged from 3 to 86 μg/dl, with 65.7% of the group at and above 10 μg/dl. Zinc protoporphyrin heme ratios (ZPP/heme) ranged from 38 to 380 μmol/mol, with 57.1% of the participants showing abnormal ZPP/heme (>69 μmol/mol). ZPP/heme was significantly correlated with PbB levels, suggesting chronic Pb exposure. Performance on the RCPM was less than average on the U.S., British, and Puerto Rican norms, but average on the Peruvian norms. Significant inverse associations between PbB/ZPP concentrations and RCPM standard scores using the U.S., Puerto Rican, and Peruvian norms were observed, indicating decreasing RCPM test performance with increasing PbB and ZPP levels. RCPM scores were significantly correlated with performance on the Digit Span test for auditory memory. Mean Digit Span scale score was less than average, suggesting auditory memory/attention deficits. In conclusion, both the RCPM and Digit Span tests were found to be effective instruments for field screening of visual-spatial reasoning and auditory memory abilities, respectively, in Pb-exposed Andean adolescents and young adults.

Age-Related Impairments of Mobility Associated with Cobalt and Other Heavy Metals: Data from NHANES 1999-2004

Age-Related Impairments of Mobility Associated with Cobalt and Other Heavy Metals: Data from NHANES 1999-2004
Exposure to heavy metals promotes oxidative stress and damage to cellular components, and may accelerate age-related disease and disability. Physical mobility is a validated biomarker of age-related disability and is predictive of hospitalization and mortality. Our study examined associations between selected heavy metals and impaired lower limb mobility in a representative older human population. Data for 1615 adults aged ≥60 yr from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2004 were used to identify associations between urinary concentrations of 10 metals with self-reported and measured significant walking impairments. Models were adjusted for confounding factors, including smoking. In models adjusted for age, gender, and ethnicity, elevated levels of cadmium, cobalt, and uranium were associated with impairment of the ability to walk a quarter mile. In fully adjusted models, cobalt was the only metal that remained associated: the odds ratio (OR) for reporting walking problems with a 1-unit increase in logged cobalt concentration (μg/L) was 1.43 (95% CI 1.12 to 1.84). Cobalt was also the only metal associated with a significant increased measured time to walk a 20-ft course. In analyses of disease categories to explain the mobility finding, cobalt was associated with physician diagnosed arthritis (1-unit increase OR = 1.22 (95% CI 1.00 to 1.49). Low-level cobalt exposure, assessed through urinary concentrations of this essential heavy metal, may be a risk factor for age-related physical impairments. Independent replication is needed to confirm this association.

Surveillance Results of Depleted Uranium-Exposed Gulf War I Veterans: Sixteen Years of Follow-Up

Surveillance Results of Depleted Uranium-Exposed Gulf War I Veterans: Sixteen Years of Follow-Up

Abstract

As part of a longitudinal surveillance program, 35 members of a larger cohort of 77 Gulf War I veterans who were victims of depleted uranium (DU) “friendly fire” during combat underwent a 3-day clinical assessment at the Baltimore Veterans Administration Medical Center (VAMC). The assessment included a detailed medical history, exposure history, physical examination, and laboratory studies. Spot and 24-h urine collections were obtained for renal function parameters and for urine uranium (U) measures. Blood U measures were also performed. Urine U excretion was significantly associated with DU retained shrapnel burden (8.821 μg U/g creatinine [creat.] vs. 0.005 μg U/g creat., p = .04). Blood as a U sampling matrix revealed satisfactory results for measures of total U with a high correlation with urine U results (r = .84) when urine U concentrations were ≥0.1 μg/g creatinine. However, isotopic results in blood detected DU in only half of the subcohort who had isotopic signatures for DU detectable in urine. After stratifying the cohort based on urine U concentration, the high-U group showed a trend toward higher concentrations of urine β2 microglobulin compared to the low-U group (81.7 v. 69.0 μg/g creat.; p = .11 respectively) and retinol binding protein (48.1 vs. 31.0 μg/g creat.; p = .07 respectively). Bone metabolism parameters showed only subtle differences between groups. Sixteen years after first exposure, this cohort continues to excrete elevated concentrations of urine U as a function of DU shrapnel burden. Although subtle trends emerge in renal proximal tubular function and bone formation, the cohort exhibits few clinically significant U-related health effects.

Laser relief for neck pain

Laser relief for neck pain:
"Low-level laser therapy that uses non-thermal laser irradiation applied to the site of pain, reduces pain immediately after treatment in acute neck pain and up to 22 weeks after treatment in patients with chronic neck pain."